. 2016 Sep 26;9:452. doi: 10.1186/s13104-016-2258-1

Table 1.

Sequences of novel BK analogs with N-terminal extensions compared to that of parent peptides in each category (italicized names)

Peptide	Position											Binding competition IC₅₀ nM (95 % C.L.)
Peptide	−1	0	1	2	3	4	5	6	7	8	9	Binding competition IC₅₀ nM (95 % C.L.)
B₂ receptor agonists
First parent peptide: BK			Arg	Pro	Pro	Gly	Phe	Ser	Pro	Phe	Arg-COOH	8.2 (6.0–11.2)
Second parent peptide: B-9972		D-Arg	Arg	Pro	Hyp	Gly	Igl	Ser	Oic	Igl	Arg-COOH	17.3 (13.3–22.4)
B-10666 = Cy7-B-9972	Cy7	D-Arg	Arg	Pro	Hyp	Gly	Igl	Ser	Oic	Igl	Arg-COOH	598 (481–742)
B₂ receptor antagonists
Parent peptide: B-9430		D-Arg	Arg	Pro	Hyp	Gly	Igl	Ser	D-Igl	Oic	Arg-COOH	42.6 (20.0–90.8)
B-10665 = Cy7-B-9430	Cy7	D-Arg	Arg	Pro	Hyp	Gly	Igl	Ser	D-Igl	Oic	Arg-COOH	25.7 (11.5–57.1)

Cy7, cyanine dye 7; Hyp, trans-4-hydroxyproline; Igl, α-(2-indanyl)glycine; Oic, (3as, 7as)-octahydroindole-2-carboxylic acid; Tic, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid