Figure 2.

Time courses of CSF inflammatory mediators segregate survivors from non-survivors. In addition to the clinical and demographic data, inflammatory mediator data were collected from all 34 patients. The data were plotted as time series for the following 13 cytokines/chemokines. The inflammatory mediator time series variables varied in both in length and in the time sequence at which they were collected. (A–M) Time course analyses for each of 13 inflammatory mediators revealed differences in 6 mediators over 5 days by Two-Way ANOVA, IL-4, 5, 6, 8, 13, and TNF-α. The mediator levels were highly variable, oscillating frequently and at relatively low levels. (N,O) Notably, levels of IL-6 and IL-8 were the only mediators with mean values elevated above 1000 pg/ml.