Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Sep 27;7:342. doi: 10.3389/fphar.2016.00342

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Abboud, Mi, Puccio, Okonkwo, Buliga, Constantine and Vodovotz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Survivors and non-survivors share a similar core inflammatory wiring. (A) PCA analysis was carried out on survivor and non-survivor data combined to assess the underlying inflammatory process. This analysis identified a linear combination of TNF-α, MIP-1α, MIP-1β, IL-8, IL-10, and IL-6 as part of the first principal component. (B,C) We next carried out this analysis separately on survivors and non-survivors, with the null hypothesis being that there would not be any significant differences between these groups based on PCA if the core inflammatory “wiring” was overall similar across patients (and if the ultimate life and death outcome were due to a differential activation of this “wiring” due to different initial conditions or patient-specific characteristics. The first 4 principal components driving inflammation in survivors and non-survivors were IL-6, IL-10, MIP-1β, and IL-8.