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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2015 Oct;39(10):1357–1362. doi: 10.1097/PAS.0000000000000451

Figure 3.

Figure 3

Mutation pattern in NF1. The y-axis refers to the number of mutations and the x-axis to the amino acids. NF1 contains a Ras-GAP domain (GTPase-activator protein for Ras-like GTPase) between amino acids 1256–1451, and a CRAL-TRIO domain between amino acids 1591–1736. Missense mutations are displayed in green, nonsense mutations in red, and splice-site mutations in black. Missense and nonsense mutations are annotated to the protein level. Splice-site mutations are referenced to the coding DNA sequence.