Table 1.

Desmoplastic melanoma – clinical findings, pathologic features, and NF1 mutation status.

Case #	Age, Sex	Site	MIS	Thickness	Clark Level	DM Type	NF1 Mutation
							Mutation Type	cDNA	Protein
1	82M	Scalp	Yes	1.9 mm	V	Pure	Nonsense	c.3562C>T	p.Q1188*
2	24M	Arm	Yes	9.5 mm	V	Pure	Nonsense	c.2875C>T	p.Q959*
3	85F	Face	Yes	7.2 mm	V	Pure	Nonsense	c.1555C>T	p.Q519*
							Splicesite	c.7456-1G>A	p.? (splice)
4	81F	Shoulder	Yes	1.5 mm	IV	Pure	Missense	c.2530C>T	p.L844F
							Nonsense	c.2734C>T	p.Q912*
5	77F	Face	Yes	2.5 mm	IV	Pure	Nonsense	c.1105C>T	p.Q369*
							Missense	c.2146G>C	p.E716Q
6	66M	Scalp	Yes	7 mm	V	Pure	Missense	c.6472C>T	p.R2179C
							Nonsense	c.1713G>A	p.W571*
							Missense	c.3496G>A	p.G1166S
7	76M	Scalp	Yes	1.8 mm	V	Mixed	Missense	c.451A>C	p.N151H
							Missense	c.6782A>T	p.H2261L
8	85M	Neck	No	18 mm	V	Mixed	Nonsense	c.3313A>T	p.K1105*
							Nonsense	c.3826C>T	p.R1276*
9	82M	Scalp	Yes	16 mm	V	Mixed	Splicesite	c.3198-2A>C	p.? (splice)
10	67M	Face	Yes	3 mm	IV	Mixed	Nonsense	c.532G>T	p.E178*
							Frameshift	c.1968_1969delCT	p.A656fs
11	58M	Shoulder	No	11.5 mm	V	Mixed	Splicesite	c.1062+1G>A	p.? (splice)
12	66M	Scalp	Yes	15 mm	V	Mixed	Splicesite	c.4174-2A>T	p.? (splice)
13	51M	Chest	Yes	9.5 mm	V	Mixed	Missense	c.1327T>C	p.F443L
14	49F	Nose	Yes	15 mm	V	Mixed	Splicesite	c.1393-1G>A	p.? (splice)
							Nonsense	c.2088G>A	p.W696*
15	37F	Trunk	No	25 mm	V	Pure	-	-	-

Abbreviations: M = male; F = Female; MIS = melanoma in situ; mm = millimeter; DM = desmoplastic melanoma; NF = neurofibromin