FIG 1.

Metabolic engineering for the production of isoprenoid-based biofuels in a prokaryotic host. Solid arrows indicate endogenous/homologous pathways/genes, and dashed arrows indicate heterologous pathways/genes in a prokaryotic host. EDP, Entner-Doudoroff pathway; PPP, pentose phosphate pathway; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; MVA, mevalonate; G3P, glyceraldehyde-3-phosphate; DXP, deoxyxylulose-5-phosphate; MEP, 2-C-methylerythritol-4-phosphate; MECP, 2-C-methylerythritol-2,4-cyclodiphosphate; IPP, isoprenyl diphosphate; DMAPP, dimethylallyl diphosphate; GPP, geranyl pyrophosphate; FPP, farnesyl pyrophosphate; GPPS, geranyl pyrophosphate synthase; PS, pinene synthase; FS, farnesene synthase; BIS, bisabolene synthase.