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Protection of C57BL/6 mice by vaccination with viable Δcps1 strain. Total lung CFU 14 days following challenge with 90 spores of C. posadasii were significantly reduced in mice vaccinated with the Δcps1 strain (d-cps1 IP or d-cps1 SC) compared to the positive-control chimeric antigen (Chim Ag) (P = 0.001) or adjuvant alone (Adj Only) (P = 0.001).
