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N. meningitidis lipid A architecture and structure modification by LpxL1 and PagL. N. meningitidis lipid A consists of a bisphosphorylated glucosamine disaccharide with hexa-acyl chains. Deletion of the lpxL1 gene prevents the addition of the secondary lauroyl chain at the 2′ position. Expression of PagL removes the 3-hydroxydodecanoic acid moiety at the 3 position. Both modifications result in a penta-acylated lipid A structure.
