FIG 5.

Cytokine and SOCS profiles in the spleen of T. cruzi-infected AhR KO and WT mice. WT and AhR KO mice were infected with 1 × 10³ trypomastigotes. Spleens of T. cruzi-infected WT and AhR KO mice were processed for total RNA extraction. mRNA levels of IL-6, TNF, IL-17A, and Foxp3 (A) and of IL-10, SOCS1, SOCS2, and SOCS3 (B) were quantified 10 and 15 days postinfection (dpi) by quantitative RT-PCR (qRT-PCR) and are represented as 2^−ΔΔCT values. Data were normalized to those of uninfected WT or AhR KO mice. Data are presented as means ± SEM and represent the results of two independent experiments. **, P < 0.01; *, P < 0.05.