TABLE 1.
Number of mice with residual liver, spleen, and lung infection on day 7 (liver and spleen) or 21 (lungs) post-aerosol challenge compared to the total number of immunized mice
| Organ(s) and day post-aerosol challengea | Mouse strain | No. of infected mice/total no. of mice tested |
P value | |
|---|---|---|---|---|
| β-Gal DNAb | mgtCMAB DNA | |||
| Liver | ||||
| 7 | ΔF508 | 5/6 | 2/5 | 0.24 |
| 7 | WT FVB | 4/6 | 5/6 | 1 |
| Spleen | ||||
| 7 | ΔF508 | 5/6 | 1/5 | 0.08 |
| 7 | WT FVB | 2/6 | 4/6 | 0.56 |
| Lungs | ||||
| 21 | ΔF508 | 7/7 | 2/6 | 0.02 |
| 21 | WT FVB | 6/8 | 7/8 | 1 |
a
Days with significant results based on the CFU analysis (Fig. 5) are taken into account.
b
β-Gal, β-galactosidase.