Table I.
Clinical and laboratory features of scrub typhus-associated HLH in children.
| Patients | Gender/age | Diagnosis prior to admission | Duration of fever prior to admission, days | Fever/eschar/lymphadenopathy/hepatosplenomegaly | Other presentations | Blood profile Hg <90 g/l/PLT <100×109/l/WBC <4×109/l | Biochemistry ALT >120 U/l/LDH >1,000 U/l/FTG >3 mmol/l/ALB <20 g/l | Coagulation PT >15 sec/APTT >45 sec/FIB <1.5 g/l | Ferritin >1,500 µg/ml/hemophago-cytosis |
|---|---|---|---|---|---|---|---|---|---|
| Case 1 | M/8 m | Pneumonia | 9 | +/+/+/+ | Respiratory and abdom-, inal symptoms, seizure, intracranial hemorrhage | +/+/+ | +/+/+/+ | +/+/+ | +/+ |
| Case 2 | F/1 y 3 m | Pneumonia | 4 | +/+/+/+ | Respiratory and abdom-, inal symptoms, jaundice | +/+/− | +/+/+/+ | +/+/+ | +/+ |
| Case 3 | M/7 y | Pneumonia | 12 | +/+/+/+ | Respiratory and abdominal symptoms | +/+/+ | +/−/+/+ | +/+/+ | +/+ |
| Case 4 | F/7 y | Scrub typhus | 9 | +/+/+/+ | Respiratory and abdominal symptoms | +/+/+ | −/+/+/+ | +/+/+ | +/+ |
| Case 5 | M/11 y | EBV-HLH | 7 | +/+/+/+ | Respiratory symptoms | +/+/− | +/+/+/+ | +/+/+ | +/+ |
| Case 6 | M/7 y | HLH | 7 | +/+/+/+ | Respiratory and abdom-inal symptoms, hematuria | +/+/+ | +/−/+/+ | +/+/+ | +/+ |
EBV, Epstein-Barr virus; HLH, hemophagocytic lymphohistiocytosis; Hg, hemoglobin; PLT, platelet; WBC, white blood cell; ALT, alanine aminotransferase; LDH, lacate dehydrogenase; FTG, fasting triglyceride; ALB, albumen; PT, prothrombin time; APTT, activated partial thromboplastin time; FIB, fibrinogen; M, male; F, female; m, month; y, year.