Table II.
Top five enriched gene ontology terms in biological process, cellular component and molecular function categories for upregulated DEGs.
| A, Biological process | ||||
|---|---|---|---|---|
| GO_ID | Term | Count | P-value | DEGs |
| GO:0044281 | Small molecule metabolic process | 99 | 1.87×10−9 | ABCC3, ACAA1, B3GNT3, CD320, DDX11, ECHS1, FA2H, GAPDH, UQCRFS1, WNT11a |
| GO:0055114 | Oxidation-reduction process | 44 | 9.79×10−9 | ACAA1, ACSS2, COX8A, ECHS1, FA2H, HMOX1, UQCRC1, UQCRC2, UQCRFS1, VAT1a |
| GO:0044710 | Single-organism metabolic process | 137 | 3.01×10−8 | ABCC3, ACAA1, B3GNT3, BMP4, PCBD1, PSMD8, RHOB, VAT1, WNT11, XRCC6a |
| GO:0043436 | Oxoacid metabolic process | 44 | 6.07×10−8 | ABCC3, ACAA1, B3GNT3, CKMT1A, ECHS1, SOD1, SULT2B1, TPI1, TST, UGT1A6a |
| GO:0006082 | Organic acid metabolic process | 44 | 9.50×10−8 | ABCC3, ACAA1, B3GNT3, CKMT1A, GOT1, SERINC2, SLC2A1, TPI1, TST, UGT1A6a |
| B, Cellular component | ||||
| GO_ID | Term | Count | P-value | DEGs |
| GO:0005576 | Extracellular region | 138 | 3.64×10−23 | ADIRF, BMP4, CAPG, IL1RN, ITGA3, ITGA6, ITGB4, ITGB5, VAT1, VDAC1a |
| GO:0031982 | Vesicle | 129 | 5.68×10−20 | ADIRF, AHNAK2, ENO1, ITGA3, ITGB4, ITGB5, SFN, UQCRC2, VASP, VAT1a |
| GO:0031988 | Membrane-bounded vesicle | 126 | 4.25×10−18 | ADIRF, ATP6AP1, BAIAP2L2, CAPG, EPS8L1, FTH1, FURIN, GAPDH, UQCRC2, VASPa |
| GO:0043230 | Extracellular organelle | 118 | 2.21×10−18 | ADIRF, GOT1, ITGA3, ITGB4, ITGB5, KLK14, UGT1A6, UPK3B, UQCRC2, VASPa |
| GO:0044421 | Extracellular region | 131 | 8.27×10−13 | ADIRF, HMOX1, IL1RN, ITGA3, ITGA6, ITGB4, ITGB5, KLK14, TXN, WNT11a |
| C, Molecular function | ||||
| GO_ID | Term | Count | P-value | DEGs |
| GO:0005515 | Protein binding | 182 | 7.34×10−7 | AATK, HSP90AA1, IRF2BP1, ITGA3, ITGA6, ITGB4, ITGB5, UQCRFS1, VASP, VDAC1a |
| GO:0016491 | Oxidoreductase activity | 31 | 9.29×10−7 | ACAA1, GAPDH, HMOX1, HPDL, HR, LDHA, MAOB, NDUFS3, PCBD1, PIRa |
| GO:0043236 | Laminin binding | 6 | 7.96×10−6 | ECM1, GPC1, ITGA3, ITGA6, LGALS1, LYPD3 |
| GO:0050840 | Extracellular matrix binding | 7 | 2.07×10−5 | ECM1, GPC1, GPR56, ITGA3, ITGA6, LGALS1, LYPD3 |
| GO:0008106 | Alcohol dehydrogenase (NADP+) activity | 4 | 3.68×10−5 | AKR1B1, AKR1C2, AKR1C3, ALDH3A1 |
GO, gene ontology; DEGs, differentially expressed genes; NADP, nicotinamide adenine dinucleotide phosphate.
a
Not all of the gene names were included in the table.