Table VI.

Top five enriched gene ontology terms in biological process, cellular component and molecular function categories for DEGs in module 2.

A, Biological process
GO_ID	Term	Count	P-value	DEGs
GO:0022904	Respiratory electron transport chain	6	4.60×10−13	CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0022900	Electron transport chain	6	5.17×10−13	CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0045333	Cellular respiration	6	6.05×10−12	CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0015980	Energy derivation by oxidation of organic compounds	6	5.80×10−10	CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0006091	Generation of precursor metabolites and energy	6	2.32×10−9	CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
B, Cellular component
GO_ID	Term	Count	P-value	DEGs
GO:0005743	Mitochondrial inner membrane	7	1.67×10−12	ATP5G3, CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0019866	Organelle inner membrane	7	3.57×10−12	ATP5G3, CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0070469	Respiratory chain	5	2.12×10−11	CYC1, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0031966	Mitochondrial membrane	7	2.30×10−11	ATP5G3, CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
GO:0005740	Mitochondrial envelope	7	3.57×10−11	ATP5G3, CYC1, COX8A, UQCRC1, NDUFS3, UQCRC2, UQCRFS1
C, Molecular function
GO_ID	Term	Count	P-value	DEGs
GO:0015078	Hydrogen ion transmembrane transporter activity	4	4.15×10−8	ATP5G3, COX8A, UQCRC1, UQCRFS1
GO:0008121	Ubiquinol-cytochrome-c reductase activity	2	3.57×10−6	UQCRC1, UQCRFS1
GO:0016681	Oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	2	3.57×10−6	UQCRC1, UQCRFS1
GO:0016679	Oxidoreductase activity, acting on diphenols and related substances as donors	2	4.76×10−6	UQCRC1, UQCRFS1
GO:0015077	Monovalent inorganic cation transmembrane transporter activity	4	6.29×10−6	ATP5G3, COX8A, UQCRC1, UQCRFS1

DEG, differentially expressed genes; GO, gene ontology; BP, biological process; CC, cellular component; MF, molecular function.