Table I.
Description of 123 patients with cervical cancer with respect to COX-2 expression.
| Variable | Overall | COX-2-negative | COX-2-positive |
|---|---|---|---|
| Total patients, n (%) | 123 | 95 (77.2) | 28 (22.8) |
| Age (years) at surgery | |||
| Mean ± SD | 52.4±12.8 | 51.5±12.4 | 55.5±13.9 |
| Range | 25–79 | 25–75 | 34–79 |
| T stage, n (%a) | |||
| ypT0 | 2 (1.6) | 2 (2.1) | 0 (0.0) |
| T1 | 77 (63.1) | 60 (63.8) | 17 (60.7) |
| T2 | 38 (31.1) | 29 (30.9) | 9 (32.1) |
| T3 | 3 (2.5) | 2 (2.1) | 1 (3.6) |
| T4 | 2 (1.6) | 1 (1.1) | 1 (3.6) |
| Tx (unknown) | 1 | 1 | 0 |
| N stage, n (%a) | |||
| N0 | 93 (75.6) | 75 (78.9) | 18 (64.3) |
| N1 | 30 (24.4) | 20 (21.1) | 10 (35.7) |
| M stage, n (%a) | |||
| M0 | 118 (95.9) | 92 (96.8) | 26 (92.9) |
| M1 | 5 (4.1) | 3 (3.2) | 2 (7.1) |
| Hemangiosis, n (%a) | |||
| Negative | 54 (96.4) | 38 (95.0) | 16 (100.0) |
| Positive | 2 (3.6) | 2 (5.0) | 0 (0.0) |
| Unknown | 67 | 55 | 12 |
| Lymphangiosis, n (%a) | |||
| Negative | 47 (68.1) | 39 (78.0) | 8 (42.1) |
| Positive | 22 (31.9) | 11 (22.2) | 11 (57.9) |
| Unknown | 54 | 45 | 9 |
| Grade, n (%a) | |||
| G1 | 2 (1.7) | 2 (2.1) | 0 (0.0) |
| G2 | 56 (46.7) | 43 (45,7) | 13 (50.0) |
| G3 | 62 (51.7) | 49 (52,1) | 13 (50.0) |
| Gx (unknown) | 3 | 2 | |
| FIGO stage, n (%a) | |||
| I | 77 (62.6) | 60 (63.2) | 17 (60.7) |
| II | 39 (31.7) | 30 (31.6) | 9 (32.1) |
| III | 5 (4.1) | 4 (4.2) | 1 (3.6) |
| IV | 2 (1.6) | 1 (1.1) | 1 (3.6) |
| History of smoking, n (%a) | |||
| Yes | 51 (41.5) | 41 (43.2) | 10 (35.7) |
| No | 72 (58.5) | 54 (56.8) | 18 (64.3) |
| Chemotherapy administered, n (%a) | |||
| Yes | 59 (49.2) | 43 (46.2) | 16 (59.3) |
| No | 61 (50.8) | 50 (53,8) | 11 (40,7) |
| Unknown | 3 | 1 | 2 |
| Radiotherapy administered, n (%a) | |||
| Yes | 75 (61.0) | 58 (61.1) | 17 (60.7) |
| No | 48 (39.0) | 37 (38.9) | 11 (39.3) |
Samples were interpreted as negative or positive for COX-2 based on immunoreactivity scores of ≤3 or ≥4, respectively.
a
Indicates the percentage of patients with known status for each variable, with respect to COX-2 expression group. COX-2, cyclooxygenase-2; SD, standard deviation; T, tumor; N, node; M, metastasis; FIGO, International Federation of Gynecology and Obstetrics; yp10, in histology no more tumor cells detectable after neoadjuvant chemotherapy.