Table I.
Clinicopathological factors and protein expression levels of adenosine triphosphate-binding cassette sub-family G (WHITE) member 2 (Junior blood group) in 189 patients with colorectal cancer.
| Characteristics | All patients, n (%) | Low-expression group, n (%) | High-expression group, n (%) | P-value |
|---|---|---|---|---|
| Total | 189 (100) | 76 (40) | 113 (60) | |
| Age, years | ||||
| Median | 65 | 64 | 66 | 0.271a |
| Range | 33–88 | 33–88 | 43–86 | |
| Gender | ||||
| Female | 77 (41) | 29 (38) | 48 (42) | 0.659b |
| Male | 112 (59) | 47 (62) | 65 (58) | |
| Tumor location | ||||
| Colon | 119 (63) | 56 (74) | 63 (56) | 0.019b |
| Rectum | 70 (37) | 20 (26) | 50 (44) | |
| Differentiation | ||||
| Well | 39 (21) | 15 (20) | 24 (21) | 0.733b |
| Moderate | 136 (72) | 54 (71) | 82 (73) | |
| Poor | 14 (7) | 7 (9) | 7 (6) | |
| Stage grouping | ||||
| Duke's A | 87 (46) | 35 (46) | 52 (46) | 1.000b |
| Duke's B, C | 102 (54) | 41 (54) | 61 (54) | |
| Tumor depth | ||||
| pT1,2 | 35 (19) | 9 (12) | 26 (23) | 0.081b |
| pT3,4 | 154 (81) | 67 (88) | 87 (77) | |
| Lymph node metastasis | ||||
| N0 | 94 (50) | 38 (50) | 56 (50) | 1.000b |
| N1,2 | 95 (50) | 38 (50) | 57 (50) | |
| Distant metastasis | ||||
| M0 | 156 (83) | 60 (79) | 96 (85) | 0.383b |
| M1 | 33 (17) | 16 (21) | 17 (15) | |
| Lymphatic invasion | ||||
| Ly0,1 | 133 (70) | 50 (66) | 83 (73) | 0.333b |
| Ly2,3 | 56 (30) | 26 (34) | 30 (27) | |
| Venous invasion | ||||
| V0,1 | 126 (67) | 49 (64) | 77 (68) | 0.714b |
| V2,3 | 63 (33) | 27 (36) | 36 (32) | |
| SN-38 effect, T/C | ||||
| Median | 66 | 55 | 73 | <0.001a |
| Range | 21–100 | 21–100 | 32–100 | |
| Sensitive, T/C <60 | 77 (41) | 56 (74) | 21 (19) | <0.001b |
| Resistant, T/C ≥60 | 112 (59) | 20 (26) | 92 (81) |
a
P-values were obtained from Student's t-tests.
b
P-values were obtained from χ2 tests. TNM, tumor-node-metastasis; T/C, ratio of the total colony volume of the treated group (T) to that of the control group (C).