Table II.
Multivariate analysis of clinicopathological factors and SN-38 sensitivity in 189 patients with colorectal cancer.
| Multivariate analysis | |||||
|---|---|---|---|---|---|
| Factors | Sensitive, n (%) | Resistant, n (%) | Univariate analysis P-valuea | Adjusted PR (95% CI) | P-valueb |
| Total | 77 (41) | 112 (59) | |||
| Age, years | |||||
| <65 | 40 (52) | 59 (53) | 1.000 | ||
| ≥65 | 37 (48) | 53 (47) | |||
| Gender | |||||
| Female | 35 (45) | 42 (38) | 0.346 | ||
| Male | 42 (55) | 70 (63) | |||
| Tumor location | |||||
| Colon | 55 (71) | 64 (57) | 0.065 | Ref | 0.446 |
| Rectum | 22 (29) | 48 (43) | 1.33 (0.63–2.77) | ||
| Differentiation | |||||
| Well | 16 (21) | 23 (21) | 0.756 | ||
| Moderate | 54 (70) | 82 (73) | |||
| Poor | 7 (9) | 7 (6) | |||
| Stage grouping | |||||
| Duke's A | 36 (47) | 51 (46) | 0.987 | ||
| Duke's B,C | 41 (53) | 61 (54) | |||
| Tumor depth | |||||
| pT1,2 | 11 (14) | 24 (21) | 0.093 | ||
| pT3,4 | 66 (86) | 88 (79) | |||
| Lymph node metastasis | |||||
| N0 | 40 (52) | 54 (48) | 0.722 | ||
| N1,2 | 37 (48) | 58 (52) | |||
| Distant metastasis | |||||
| M0 | 64 (83) | 92 (82) | 1.000 | ||
| M1 | 13 (17) | 20 (18) | |||
| Lymphatic invasion | |||||
| Ly0,1 | 53 (69) | 80 (71) | 0.824 | ||
| Ly2,3 | 24 (31) | 32 (29) | |||
| Venous invasion | |||||
| V0,1 | 53 (69) | 73 (65) | 0.714 | ||
| V2,3 | 24 (31) | 39 (35) | |||
| ABCG2 expression | |||||
| Low | 56 (73) | 20 (18) | <0.001 | Ref | <0.001 |
| High | 21 (27) | 92 (82) | 11.77 (5.83–23.76) | ||
a
P-values were obtained from χ2 tests.
b
P-values were obtained from Wald tests. TNM, tumor-node-metastasis; PR, prevalence ratio; CI, confidence interval; ABCG2, adenosine triphosphate-binding cassette sub-family G (WHITE) member 2 (Junior blood group); Ref, reference.