FIG 4.

Binding analysis of compound 4c with LdTopIB. (A) Binding sites of compound 4c on LdTopIB. Protein is shown as cartoon and the ligand in CPK model. Interacting residues are shown as sticks. (B) Interaction of compound 4c with the small subunit of LdTopIB. Residues with more than a 30% interaction fraction (i.e., common for at least 3 stereoisomers) are shown. (C) Interaction diagram of compound 4c with the hinge region of LdTopIB. Residues with more than a 30% interaction fraction are shown.