TABLE 1.
In vitro activity of DAP alone or in combination with FOF in the one-compartment PK/PD model
| Regimena | Activity (log10 CFU/ml) by strain and time pointb |
|||||||
|---|---|---|---|---|---|---|---|---|
| 8019 |
5938 |
V583 |
R7302 |
|||||
| T24 | T72 | T24 | T72 | T24 | T72 | T24 | T72 | |
| FOF | 7.73 ± 0.06 | 7.81 ± 0.01 | 6.81 ± 0.39 | 7.76 ± 0.06 | 7.95 ± 0.24 | 7.97 ± 0.57 | 8.17 ± 0.07 | 7.60 ± 0.39 |
| D8 | 4.17 ± 1.28 | 7.94 ± 0.06 | 8.08 ± 0.41 | 8.43 ± 0.30 | 6.98 ± 0.12 | 7.75 ± 0.00 | 7.29 ± 0.04 | 7.43 ± 0.24 |
| D12 | 2.36 ± 1.92 | 7.68 ± 0.21 | 8.21 ± 0.08 | 8.54 ± 0.05 | 7.57 ± 0.01 | 7.87 ± 0.02 | 7.11 ± 0.24 | 7.55 ± 0.51 |
| D8+FOF | 2.75 ± 0.64 | 4.45 ± 0.91* | 4.81 ± 0.26* | 7.79 ± 0.04 | 3.51 ± 0.35* | 5.88 ± 0.04* | 5.13 ± 0.02* | 5.69 ± 0.44* |
| D12+FOF | 1 ± 0.00 | 2.5 ± 1.27* | 4.67 ± 0.28* | 7 ± 0.17* | 3.58 ± 0.06* | 3.91 ± 0.21* | 5.01 ± 0.57* | 4.64 ± 0.02* |
a
D8, DAP 8; D12; DAP 12; D8+FOF, DAP 8 with FOF; D12+FOF, DAP 12 with FOF.
b
T24, 24-h time point; T72, 72-h time point. An asterisk indicates significantly greater log10 CFU/ml reduction over monotherapy (P ≤ 0.05).