TABLE 2.
Final three-compartment population PK model estimatesa
| Parameter | Mean | Median | SD | CV (%) |
|---|---|---|---|---|
| Ka (h−1) | 1.5 | 1.0 | 1.3 | 84.8 |
| V0/F (liter/0.3 kg) | 0.3 | 0.3 | 0.2 | 54.0 |
| kel/F (h−1) | 1.3 | 0.9 | 0.9 | 73.8 |
| K12 (h−1) | 4.8 | 1.9 | 5.3 | 110.3 |
| K21 (h−1) | 4.2 | 1.6 | 5.3 | 124.8 |
a
Mean and median population pharmacokinetic parameters along with their attendant measures of dispersion are presented. The PK model was derived from 276 observations in 42 animals. Abbreviations: CV, coefficient of variation; Ka, intercompartmental absorption rate from the peritoneal space to the central compartment; kel, central compartment elimination rate; K12 and K21, intercompartmental mass transfer rates between the central and peripheral compartments; V0, volume of distribution standardized to a 0.3-kg body weight; F, apparent bioavailability of clearance and volume, which was not estimated [i.e., CL/F = (V0 · kel)/F].