TABLE 3.
Covariance matrix in lower triangular form of the final pharmacokinetic modela
| Parameter | Covariance |
||||
|---|---|---|---|---|---|
| kel (h−1) | V0/F (liter/0.3 kg) | Ka (h−1) | K12 (h−1) | K21 (h−1) | |
| kel (h−1) | 0.866 | ||||
| V0/F (liter/0.3 kg) | −0.052 | 0.0228 | |||
| Ka (h−1) | −0.344 | 0.006 | 1.566 | ||
| K12 (h−1) | 0.971 | 0.043 | −1.473 | 28.248 | |
| K21 (h−1) | 1.418 | 0.207 | 1.102 | −4.086 | 27.62759 |
a
Abbreviations: Ka, intercompartmental absorption rate from the peritoneal space to the central compartment; kel, central compartment elimination rate; K12 and K21, intercompartmental mass transfer rates between the central and peripheral compartments; V0, volume of distribution standardized to s 0.3-kg body weight; F, apparent bioavailability of clearance and volume, which was not estimated [i.e., CL/F = (V0 · kel)/F].