FIG 3.

Relative activity of different antibiotics against LAC and UAMS-1 at 72 h in the context of a biofilm in vitro. Activity was evaluated using daptomycin (DAP), vancomycin (VAN), ceftaroline (CPT), oxacillin (OXA), telavancin (TLV), and tigecycline (TGC) at concentrations corresponding to 5×, 10×, and 20× the breakpoint MIC for each antibiotic. Results are shown as the number of CFU per catheter, with each box illustrating the maximum and minimum values observed within each experimental group and the horizontal line indicating the mean for that group. Gray bars, results observed with catheters that were not exposed to any antibiotic; white bars, results observed after exposure of UAMS-1 (top) or LAC (bottom) biofilms to the indicated antibiotics. *, significant reduction in the number of viable bacteria (P ≤ 0.05) relative to that achieved with vancomycin at the equivalent concentration; **, significant reduction relative to that achieved with daptomycin at the equivalent concentration.