FIG 5.

Comparison of the activity of lipoglycopeptide antibiotics in vitro. The activities of telavancin (TLV), oritavancin (ORV), and dalbavancin (DBV) at an equal concentration corresponding to 160× the breakpoint MIC of telavancin (19.2 μg per ml) were compared. The results obtained with catheters that were exposed to antibiotic (white bars) for 72 h relative to those obtained with catheters that were not exposed to antibiotic (gray bars) are shown. Results are shown as the number of CFU per catheter, with each box illustrating the maximum and minimum values observed within each experimental group and the horizontal line indicating the mean for that group. *, significant reduction in the number of viable bacteria (P ≤ 0.05) relative to that achieved with oritavancin; **, significant reduction relative to that achieved with dalbavancin.