FIG 1.

Activity of the compound TU112 against dormant nonculturable M. tuberculosis. Mycobacteria were incubated in the presence of different concentrations of the compound TU112 for 7 days at 37°C. Viability of mycobacteria was tested by measuring the numbers of cells recovered from a nonculturable state by most probable number (MPN) assay as described earlier (12). The difference between TU112 groups and the untreated control was significant, with a P value of <0.01. Error bars indicate standard deviation.