TABLE 2.

Antimycobacterial testing results of 3-triazenoindoles

Compounda	Activity (MIC99 [μg/ml]) againstb:			IC50 (μg/ml)c	SI ford:
	M. tuberculosis H37Rv	INHr CN-40 strain	M. avium		M. tuberculosis H37Rv	INHr CN-40	M. avium
TU90	0.46	0.46	NT	18	39	39	NT
TU91	0.36	0.45	NT	10	28	22	NT
TU111	0.25	0.5	0.1	100	400	200	2,000
TU112	0.25	0.2	0.05	18	72	90	360
TU113	>1	2–10	1	7	<7	<3.5–0.7	7
TU114	0.3	0.1–1	0.25	50	166	50–500	200
TU152	0.1–0.5	≤0.5	<0.1	50	100–500	100	500
TU167	<0.5	<0.5	2	10	>20	>20	5
INH	0.05	20	NT	NT	NT	NT	NT
RIF	0.1	0.1	NT	NT	NT	NT	NT
CLA	NT	NT	0.2	NT	NT	NT	NT

^aINH, isoniazid; RIF, rifampin; CLA, clarithromycin.

^bINH^r, INH resistant; NT, not tested.

^cIC₅₀, concentration killing 50% of host macrophages.

^dSI, selectivity index.