FIG 3.

In vivo efficacy of compound 2 (Cmp 2) in a murine GKO (C57BL/6-Ifngtm1ts) model of acute TB. Oral treatment was started 15 days (start) after infection with a low-dose aerosol of M. tuberculosis Erdman lux and continued for 9 consecutive daily treatments until day 23, when mice were euthanized on day 24 (end). CFU in lungs and spleens were determined, and means from five mice for drug-treated groups and from 6 mice per group for the untreated controls are shown. *, P < 0.001 by pairwise multiple-comparison procedures (Tukey test) compared to controls.