FIG 7.
Efficacy of compound 14 in a mouse model of chronic TB infection. C57BL/6J mice were infected with M. tuberculosis H37Rv intratracheally (∼102 CFU) and were dosed once daily for 8 weeks starting 6 weeks after infection. Mice were sacrificed 24 h after the last drug administration. Every column represents the mean values ± standard deviations of data from 7 mice per group for untreated and linezolid-treated groups and from 3 mice for compound 14-treated mice. *, P < 0.001 by pairwise multiple-comparison procedures (Tukey test) compared to controls.