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. 2016 Sep 23;60(10):6271–6280. doi: 10.1128/AAC.01339-16

TABLE 3.

Thermodynamic analysis of interactions between M. tuberculosis LeuRS and benzoxaborole compoundsa

Compound Kd (μM) ΔGap (kcal mol−1) ΔHap (kcal mol−1) −TΔSap (kcal mol−1) No. of sites
2 3.7 −7.4 −1.1 −6.3 1.05
13 0.075 −9.7 −4.2 −5.5 1.19
11 0.040 −10.0 −5.5 −4.6 1.02
a

The errors in the thermodynamic binding parameters are ∼5% for the apparent binding enthalpy and 10% for the apparent binding constant and the number of sites. Kd, dissociation constant; ΔG, change in Gibb's free energy; ΔH, change in enthalpy; ΔS, change in entropy. Values are the averages of data from at least 2 independent experiments.