TABLE 5.
Mitochondrial protein synthesis inhibitiona
| Compound | Mean EC50 (μM) ± SD |
||
|---|---|---|---|
| COX1 | SDHA | Cell viability | |
| Compound 12 | >150 | 39.5 ± 9.2 | 23.0 ± 1.4 |
| Compound 13 | >150 | 20.5 ± 2.1 | 80.0 ± 5.7 |
| Compound 14 | >150 | 21.5 ± 6.4 | 106 ± 37.5 |
| Linezolid | 27.3 ± 10.8 | >150 | >150 |
| Chloramphenicol | 31.4 ± 23.2 | >150 | 110 ± 14.1 |
| Doxycycline | 23.7 ± 6.4 | 109 ± 29 | 118 ± 35.5 |
| Erythromycin | >150 | >150 | >150 |
a
COX1 is cytochrome c oxidase, which is a mitochondrial protein that is synthesized by mitochondrial ribosomes. SDHA is subunit A of the succinate dehydrogenase complex, which is a mitochondrial protein that is synthesized by cytoplasmic ribosomes. Janus green staining was used to determine cell viability after 7 days.