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. 2016 Sep 23;60(10):6155–6164. doi: 10.1128/AAC.01277-16

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FIG 3 — Models of OXA-172 and OXA-173. To help explain the potential structural effects of the substitutions that resulted in enhancement of hydrolytic activities, we constructed models of variants that contained those substitutions. (A) Model of OXA-66 I129V/W222L (OXA-172; magenta) superposed with a model of OXA-66 wild type (blue) and OXA-24/40/doripenem (PDB code 3PAE) (cyan; ligand only). (B) Model of OXA-66 I129V/W222L/P226L (OXA-173; yellow) superposed with a model of OXA-66 wild type (blue) and OXA-225/ceftazidime (PDB code 4X55) (salmon; ligand only). dori, doripenem; ceftaz, ceftazidime.