FIG 2.

Effects of ceftriaxone-plus-azithromycin combination therapy on bacterial burden in the lungs of mice with pneumococcal pneumonia. The bacterial burden of the right lung was assessed among treatments of ceftriaxone plus azithromycin, ceftriaxone, azithromycin, or control at day 1 (A) and day 3 (B) after infection. Treatments were applied three times every 24 h beginning at 6 h after infection. Data are presented as means ± SEM (n = 5) and were statistically analyzed using one-way ANOVA followed by a Turkey's post hoc test. ††, P < 0.01 compared with treatment of the control group on day 1; †††, P < 0.001 compared with treatment of the control group on day 1; *, P < 0.05 compared with treatment of the azithromycin group on day 3.