TABLE 1.
Effects of novel suppressors on ciprofloxacin MIC
| Additional suppressor allelea | Fitness ratiob | Genetic background MIC (μg/ml) |
||
|---|---|---|---|---|
| rCip-8 | Wild type | rCip-8ΔacrB | ||
| None | 1 | 28 | 0.015 | 1 |
| ΔhofO | 0.53 | 20 | 0.015 | 1 |
| ΔygaH | 0.43 | 16 | 0.015 | 1 |
| ΔlpxM | 0.36 | 16 | 0.007 | 0.5 |
| ΔmiaA | 0.3 | 16 | 0.007 | 1 |
| ΔyciS | 0.24 | 10 | 0.007 | 1 |
a
All suppressor alleles are gene knockouts, tested with the Kanr cassette present and removed.
b
The fitness ratio corresponds to the relative abundance of alleles carrying transposon insertions in their respective genes.