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. 2016 Sep 23;60(10):5631–5639. doi: 10.1128/AAC.00324-16

FIG 6.

FIG 6

Levels of the inflammatory cytokines Il-6 and CXCL1 in untreated and treated mice that died from pulmonary aspergillosis infection (a) and treated mice that survived the infection (b). The deceased mouse groups included 8 mice receiving the placebo, 5 receiving caspofungin (5 mg/kg/day), 5 receiving phenanthroline (10 mg/kg/day), and 1 receiving TPEN (5 mg/kg/day). The survivor group included 4 uninfected mice that received TPEN (5 mg/kg/day), 6 that received caspofungin (10 mg/kg/day), 7 that received phenanthroline (10 mg/kg/day), 7 that received the combination (5 mg/kg/day TPEN and 5 mg/kg/day caspofungin), and 10 that received TPEN (5 mg/kg/day). No significant differences were observed among the deceased mice. Phenanthroline versus uninfected, P = 0.0468 for IL-6 and P = 0.0169 for CXCL1; combination versus uninfected, P = 0.0424 for IL-6 and P = 0.0338 for CXCL1; TPEN versus uninfected, P = 0.0204 for IL-6 and P = 0.0022 for CXCL1.