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PD simulations. (A) Exemplary simulation of mycobacterial counts in human lungs following QD oral administration of 600 mg INH for 2 days of treatment. Simulation results for an untreated immune-deficient (ID) patient, an untreated immunocompetent (IC) patient, and an immunocompetent INH-treated patient are shown. (B) Observed (23, 45) versus predicted EBA after 2 days of INH chemotherapy for slow, intermediate, and fast acetylators receiving QD INH doses ranging from 9 mg to 600 mg.
