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Kinetic parameters for metabolic reactions of INH PBPK model
| Enzymatic reaction |
Vmax (μmol · liter−1 · min−1) |
Km (μmol · liter−1) | |||
|---|---|---|---|---|---|
| All subjects | Slow acetylators | Intermediate acetylators | Fast acetylators | ||
| NAT2INH | 50 | 225 | 400 | 1,950 | |
| NAT2Hz | 6 | 27 | 48 | 320 | |
| NAT2AcHz | 0.5 | 2.25 | 4 | 10 | |
| NAAAINH | 4 | 2,000 | |||
| NAAAAcINH | 3 | 500 | |||
| GLYATINA | 0.25 | 10 | |||
| SLC16A10INA | 15 | 300 | |||
| SLC16A10INAG | 1 | 10 | |||
