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PBPK/PD model parameters
| Parameter | Value | Reference(s) or source |
|---|---|---|
| N0 | 10 log10 CFU · liter−1 | Arbitrary |
| μ | 0.048 · day−1 | (5, 6, 23, 43–46)a |
| β0 | 0.0219 · day−1 | (42, 70)a |
| Emax | 0.534 · day−1 | Fitted |
| Km | 25.19 μmol · liter−1 | Fitted |
| h | 0.56 | Fitted |
| MIC | 1.46 μmol · liter−1 | 41 |
A detailed calculation is provided in the supplemental material.
