FIG 2.
Structural pharmacokinetic model for micafungin in critically ill patients with intraperitoneal drains in situ. The model was linear and contained volume compartments for the central compartment (plasma; Vcentral), the peritoneal fluid compartment, and the peripheral compartment. Abbreviations: IV, intravenous; kcp, rate constant for the drug distribution from the central to the peripheral compartment; kpc, rate constant for the drug distribution from the peripheral to the central compartment; Vcentral, volume of distribution of the central compartment; kct, rate constant for the drug distribution from the central to the tissue fluid compartment; ktc, rate constant for the drug distribution from the tissue fluid to the central compartment; CL, clearance.