TABLE 2.

Parameter estimates for micafungin from the final three-compartment population PK model^a

Parameter	Mean ± SD value for:			Coefficient of variation	Median
	Burn patients (n = 15)	Intra-abdominal infection patients (n = 10)	All patients (n = 25)
CL (liters/h)	1.61 ± 0.62	1.09 ± 0.72	1.38 ± 0.70	50.93	1.33
Vcentral (liters)	6.07 ± 2.77	5.85 ± 1.02	5.87 ± 2.44	41.55	5.21
kct (h−1)	0.59 ± 0.31	0.42 ± 0.35	0.43 ± 0.34	77.37	0.40
ktc (h−1)	0.47 ± 0.47	0.15 ± 0.06	0.32 ± 0.42	131.47	0.17
kcp (h−1)	16.87 ± 11.93	24.98 ± 8.03	19.93 ± 11.07	55.55	25.06
kpc (h−1)	9.93 ± 6.02	11.95 ± 4.02	9.90 ± 5.64	57.00	8.90

^aData are presented as the mean ± SD for burn patients only, intra-abdominal infection patients only, and all patients combined and as the coefficient of variation and median for all patients. Boldface data indicate a statistically significant difference (P < 0.05) between the burn and intra-abdominal infection patients. CL, clearance; V_central, volume of distribution of the central compartment; k_ct, rate constant for the drug distribution from the central to tissue fluid compartment; k_tc, rate constant for the drug distribution from the tissue fluid to the central compartment; k_cp, rate constant for the drug distribution from the central to the peripheral compartment; k_pc, rate constant for the drug distribution from the peripheral to the central compartment.