TABLE 3.

Growth or no growth of Escherichia coli ATCC 25922 in the presence of peptide-antibiotic combinations

Antibiotica	MICb (μg/ml)	Antibiotic concn (μg/ml)	Growthc
			Compound 79	Compound 33	No peptide
PEN	16	2d	+	+	+
ERY	16	0.5e	−	+	+
FUS	500	1f	−	−	+
NOV	16	1g	−	−	+
RIF	2	0.5e	−	−	+
VAN	250	4h	+	+	+
No antibiotic	NAi	NA	+	+	+

^aPEN, benzylpenicillin; ERY, erythromycin; FUS, fusidic acid; NOV, novobiocin; RIF, rifampin; VAN, vancomycin.

^bMICs of antibiotics individually.

^cCompounds 79 and 33 were tested at a concentration of 1 μM each. +, growth; −, no growth.

^dEUCAST generic breakpoint.

^eEUCAST breakpoints for Streptococcus spp.

^fEUCAST breakpoints for Staphylococcus spp.

^gArbitrary breakpoint defined in the absence of any clinical breakpoint.

^hEUCAST breakpoint for Enterococcus spp.

ⁱNA, not applicable.