TABLE 6.
Pathogen | Result for treatment group |
REL vs placebo comparison, % difference (95% CI)b |
||||||
---|---|---|---|---|---|---|---|---|
250 mg REL + IMI (n = 81) |
125 mg REL + IMI (n = 86) |
Placebo + IMI (n = 83) |
250 mg REL + IMI | 125 mg REL + IMI | ||||
n/m | % | n/m | % | n/m | % | |||
Gram-positive aerobic cocci | 32/32 | 100 | 32/33 | 97.0 | 33/34 | 97.1 | 2.9 (−8.1 to 15.1) | −0.1 (−12.9 to 12.4) |
Enterococcus faecalis | 7/7 | 100 | 5/5 | 100 | 5/5 | 100 | 0.0 (−37.4 to 45.6) | 0.0 (−46.1 to 46.1) |
Streptococcus anginosus | 5/5 | 100 | 6/6 | 100 | 7/7 | 100 | 0.0 (−45.6 to 37.4) | 0.0 (−41.0 to 37.3) |
Streptococcus constellatus | 2/2 | 100 | 5/6 | 83.3 | 6/6 | 100 | 0.0 | −16.7 (−57.9 to 28.5) |
Gram-negative aerobic bacilli | 73/75 | 97.3 | 73/73 | 100 | 68/72 | 94.4 | 2.9 (−4.4 to 11.2) | 5.6 (0.4 to 13.5) |
Enterobacter cloacae | 7/7 | 100 | 4/4 | 100 | 4/4 | 100 | 0.0 (−37.6 to 51.4) | 0.0 (−52.3 to 52.3) |
Escherichia coli | 53/55 | 96.4 | 56/56 | 100 | 47/51 | 92.2 | 4.2 (−5.7 to 15.4) | 7.8 (1.1 to 18.6) |
Klebsiella pneumoniae | 10/10 | 100 | 12/12 | 100 | 10/12 | 83.3 | 16.7 (−14.4 to 45.5) | 16.7 (−10.6 to 45.4) |
Proteus mirabilis | 8/8 | 100 | 4/4 | 100 | 6/6 | 100 | 0.0 (−34.1 to 40.8) | 0.0 (−51.6 to 41.6) |
Pseudomonas aeruginosa | 11/11 | 100 | 13/13 | 100 | 10/12 | 83.3 | 16.7 (−12.4 to 45.5) | 16.7 (−9.0 to 45.4) |
Gram-negative anaerobic bacilli | 22/24 | 91.7 | 30/30 | 100 | 26/27 | 96.3 | −4.6 (−23.0 to 11.4) | 3.7 (−8.1 to 18.5) |
Bacteroides fragilis | 11/11 | 100 | 8/8 | 100 | 12/12 | 100 | 0.0 (−26.7 to 25.1) | 0.0 (−33.6 to 25.2) |
Bacteroides thetaiotaomicron | 6/6 | 100 | 6/6 | 100 | 6/7 | 85.7 | 14.3 (−29.9 to 52.8) | 14.3 (−29.9 to 52.8) |
The most common pathogens (those with at least 15 unique baseline isolates) are shown. CI, confidence interval; IMI, imipenem-cilastatin; n/m, number of subjects with pathogen and favorable clinical response/number of subjects with pathogen and clinical response assessment. Subjects with an indeterminate or missing response are excluded from the analysis.
The 95% confidence intervals are based on the unconditional asymptotic Miettinen and Nurminen method without stratification.