TABLE 6.

Proportion of subjects in the ME population with favorable clinical response at DCIV by baseline pathogen^a

Pathogen	Result for treatment group						REL vs placebo comparison, % difference (95% CI)b
	250 mg REL + IMI (n = 81)		125 mg REL + IMI (n = 86)		Placebo + IMI (n = 83)		250 mg REL + IMI	125 mg REL + IMI
	n/m	%	n/m	%	n/m	%
Gram-positive aerobic cocci	32/32	100	32/33	97.0	33/34	97.1	2.9 (−8.1 to 15.1)	−0.1 (−12.9 to 12.4)
Enterococcus faecalis	7/7	100	5/5	100	5/5	100	0.0 (−37.4 to 45.6)	0.0 (−46.1 to 46.1)
Streptococcus anginosus	5/5	100	6/6	100	7/7	100	0.0 (−45.6 to 37.4)	0.0 (−41.0 to 37.3)
Streptococcus constellatus	2/2	100	5/6	83.3	6/6	100	0.0	−16.7 (−57.9 to 28.5)
Gram-negative aerobic bacilli	73/75	97.3	73/73	100	68/72	94.4	2.9 (−4.4 to 11.2)	5.6 (0.4 to 13.5)
Enterobacter cloacae	7/7	100	4/4	100	4/4	100	0.0 (−37.6 to 51.4)	0.0 (−52.3 to 52.3)
Escherichia coli	53/55	96.4	56/56	100	47/51	92.2	4.2 (−5.7 to 15.4)	7.8 (1.1 to 18.6)
Klebsiella pneumoniae	10/10	100	12/12	100	10/12	83.3	16.7 (−14.4 to 45.5)	16.7 (−10.6 to 45.4)
Proteus mirabilis	8/8	100	4/4	100	6/6	100	0.0 (−34.1 to 40.8)	0.0 (−51.6 to 41.6)
Pseudomonas aeruginosa	11/11	100	13/13	100	10/12	83.3	16.7 (−12.4 to 45.5)	16.7 (−9.0 to 45.4)
Gram-negative anaerobic bacilli	22/24	91.7	30/30	100	26/27	96.3	−4.6 (−23.0 to 11.4)	3.7 (−8.1 to 18.5)
Bacteroides fragilis	11/11	100	8/8	100	12/12	100	0.0 (−26.7 to 25.1)	0.0 (−33.6 to 25.2)
Bacteroides thetaiotaomicron	6/6	100	6/6	100	6/7	85.7	14.3 (−29.9 to 52.8)	14.3 (−29.9 to 52.8)

^aThe most common pathogens (those with at least 15 unique baseline isolates) are shown. CI, confidence interval; IMI, imipenem-cilastatin; n/m, number of subjects with pathogen and favorable clinical response/number of subjects with pathogen and clinical response assessment. Subjects with an indeterminate or missing response are excluded from the analysis.

^bThe 95% confidence intervals are based on the unconditional asymptotic Miettinen and Nurminen method without stratification.