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(A) Proportion of mcr-1-positive E. coli strains among ESBL-producing E. coli isolates from French calves and linear trend of the evolution between 2006 and 2014. Upper and lower limits of confidence intervals at 95% of the mcr-1 proportion are shown. (B) Trends in weights of animals treated (WAT) (bovines) with polypeptidic antibiotics (almost exclusively represented by colistin) or extended-spectrum cephalosporins.
