TABLE 2.

NS5A RAMs detected at baseline in GT1 patients by deep sequencing

HCV genotype	Dose (mg)	Patient	Baseline RAM	RAM frequency (%)	Maximum RNA reduction (log10 IU/ml)
					Patient	Cohort mean
1a	10	5306	M28V	2	2.91	2.08
	10	5310	K24R	2	2.54
			M28V	2
	10	5314	K24R	4	1.21
			Q30H	44
	10	5407a	M28V	23	1.68
			H58R	2
			Y93F	28
	30	5313	Q30R	4	1.42	2.32
	100	5308	M28V	2	2.74	3.58
	200	5304	M28V	29	3.24	3.39b
	200	5305	K24N	3	0.56
			K24R	3
			K24S	1
			M28T	90
			Q30H	56
			Q30L	2
			Q30R	13
			F36L	99
			H58D	1
			H58R	1
	200	5309	M28V	43	3.58
			E62V	25
1b	10	5404	Y93H	4	4.14	3.90
	30	5414	Y93H	99	2.79	3.50
	100	5402	R30Q	76	4.37	4.36
	200	5403	P58S	99	4.02	3.80
	200	5411	R30Q	100	2.99
			Q62R	100

^aIncorrectly identified as infected with GT1b HCV at screening.

^bResults for patient 5305 excluded from mean calculation due to viral RNA level of <10⁵ IU/ml at baseline.