TABLE 3.
Numbers of patients with NS5A RAMs detected by deep sequencing across dosing cohorts at nadir viral RNA level
| Genotype | Mutation | No. of GT1a or GT1b patients receiving indicated dose of EDP-239 with NS5A RAMs at nadir |
|||
|---|---|---|---|---|---|
| 10 mg | 30 mg | 100 mg | 200 mg | ||
| 1a | K24R | 2 | 1 | ||
| K24N | 1 | ||||
| M28A | 1 | ||||
| M28T | 2 | 3 | 2 | 1 | |
| M28V | 3 | 1 | 1 | 2 | |
| Q30H | 4 | 3 | 1 | ||
| Q30E | 1 | 3 | |||
| Q30R | 3 | 3 | 3 | 3 | |
| L31M | 3 | ||||
| L31V | 1 | ||||
| F36L | 1 | 1 | |||
| H58D | 3 | 2 | 1 | ||
| H58L | 1 | ||||
| H58C | 1 | ||||
| A92T | 2 | ||||
| Y93C | 2 | 2 | 1 | 1 | |
| Y93F | 1 | ||||
| Y93H | 2 | 2 | 1 | 2 | |
| Y93N | 1 | 1 | |||
| Y93S | 1 | ||||
| 1b | L28M | 1 | |||
| R30Q | 1 | 1 | 1 | ||
| R30H | 1 | ||||
| L31F | 1 | ||||
| L31V | 2 | ||||
| L31M | 1 | ||||
| P58S | 1 | 1 | |||
| Q62P | 1 | ||||
| Q62R | 1 | ||||
| A92K | 1 | ||||
| Y93C | 1 | 1 | 1 | ||
| Y93H | 1 | 2 | 1 | ||
| Y93N | 1 | ||||