TABLE 6.
Persistence of NS5A RAMs through postdose week 12, 24, or 48
| GT | Dose | Patient | RAM(s) persistent up to wk 48 (%)a |
|---|---|---|---|
| 1a | 10 | 5306 | UNK |
| 10 | 5310 | Q30H(1)/R(37), L31M(43), H58D(2), Y93N(7)/C(8) | |
| 10 | 5314 | Q30H(56)/R(13), F36L(1) | |
| 10 | 5407b | K24R(2), M28V(66), Q30H(8)/R(80), L31M(2), H58C(15)/D(2), Y93F(12) | |
| 30 | 5303 | Q30H(14)/R(79), H58D(3) | |
| 30 | 5307 | ND | |
| 30 | 5313 | UNK | |
| 100 | 5301 | M28T(2), L31M(77) | |
| 100 | 5308 | M28T(5)/V(4), Q30H(2)/R(78), L31M (1), Y93C(2) | |
| 100 | 5311c | M28T(63), Q30R(53) | |
| 200 | 5304 | UNK | |
| 200 | 5305 | UNK | |
| 200 | 5309 | UNK | |
| 1b | 10 | 5404 | UNK |
| 10 | 5409 | ND | |
| 30 | 5405 | Y93H(3) | |
| 30 | 5413c | ND | |
| 30 | 5414 | Y93H(99) | |
| 100 | 5402 | L28 M(6), R30Q(16), L31 M(35), Y93H(37)/N(45) | |
| 100 | 5406b | R30G(3), L31V(46)/M(2), Y93H(4) | |
| 100 | 5410 | L31M(12), Y93H(10) | |
| 200 | 5403 | UNK | |
| 200 | 5408c | L31V(2)/M(97), Y93H(92) | |
| 200 | 5411b | L28 M(58), R30Q(5)/H(95) |
UNK, no data for week 12, 24, or 48; ND, no RAMs detected.
Week 12 persistence.
Week 24 persistence.