TABLE 6.
Challenge dose in cynomolgus macaque monotherapy studies
| Study | n | Challenge dose (LD50 CFU/animal) |
|
|---|---|---|---|
| Geometric mean (%CV) | 95% CI | ||
| M1 | 43 | 191 (30.06) | 175, 209 |
| M2 | 48 | 208 (20.59) | 196, 221 |
| M3a | 48 | 280 (25.04) | 261, 301 |
| M4b | 50 | 252 (20.10) | 238, 267 |
a
Tukey's pairwise comparisons with the following studies were significant at the 0.05 level: M1 (ratio of geometric study means, 1.47) and M2 (ratio of geometric study means, 1.35).
b
Tukey's pairwise comparisons with the following studies were significant at the 0.05 level: M1 (ratio of geometric study means, 1.32) and M2 (ratio of geometric study means, 1.21).