FIG 2.
Protection in murine CA-MRSA pneumonia model is dependent on alpha-hemolysin neutralization. Kaplan-Meier survival curves are shown for three independent experiments performed with 5 BALB/cJRj mice per group (n = 15 animals per experimental group). At 24 h prior to lethal intranasal challenge with 8.0 × 108 CFU S. aureus strain SF8300, animals were immunized intraperitoneally with 200 μg (∼10 mg/kg of body weight) of Hla-F#5, Hla-specific, or control MAb. Indicated P values were calculated by log-rank (Mantel-Cox) test.