TABLE 2.

Results for plasma and ELF PK parameters for ceftaroline in healthy subjects following last i.v. infusion on day 4

Parameter and dosage regimene	Value(s) (mean ± SD) for:
	Plasmaa (n = 25)	ELFb (n = 25)
600 mg q12h
Cmax, mg/liter	19.7 ± 2.72	3.38
tmax, hc	1.0 (0.97–1.10)	1.0
t1/2, h	2.41 ± 0.29	1.95
AUC0–τ, mg · h/liter	45.0 ± 7.32	8.09
% penetrationd	NA	22.5
600 mg q8h
Cmax, mg/liter	22.3 ± 3.23	3.56
tmax, h	1.0 (0.98–1.13)	1.0
t1/2, h	2.48 ± 0.31	1.81
AUC0–τ, mg · h/liter	53.0 ± 7.16	9.36
% penetration	NA	23.6

^aBased on total drug concentration in plasma. NA, not applicable.

^bBased on median ELF concentration at each time point, n = 5 subjects per time point.

^cMedian (minimum-maximum).

^dBased on the ratio of AUC_0–τ in ELF to AUC_0–τ in plasma, assuming 20% protein binding in plasma and no protein binding in ELF.

^eAbbreviations: AUC, area under the concentration-time curve; AUC_0–τ, area under the concentration-time curve from time zero to the end of the dosing interval, τ; C_max, maximum drug concentration; t_max, time of maximum drug concentration; t_1/2, terminal elimination half-life.