TABLE 4.
Percentage of simulated patients achieving fT>MIC targets in plasma
| fT>MIC target (%) and dosage regimen | % simulated patients achieving target at MIC (mg/liter) of: |
||||
|---|---|---|---|---|---|
| 0.125 | 0.25 | 0.5 | 1 | 2 | |
| 600 mg q12h, 1-h infusion | |||||
| 17 | 100 | 100 | 100 | 100 | 100 |
| 20 | 100 | 100 | 100 | 100 | 99.9 |
| 42 | 100 | 100 | 100 | 98.1 | 69.0 |
| 50 | 100 | 100 | 99.3 | 92.0 | 38.1 |
| 60 | 100 | 99.6 | 96.4 | 68.5 | 15.5 |
| 70 | 99.8 | 97.7 | 85.4 | 40 | 4.1 |
| 600 mg q8h, 1-h infusion | |||||
| 17 | 100 | 100 | 100 | 100 | 100 |
| 20 | 100 | 100 | 100 | 100 | 100 |
| 42 | 100 | 100 | 100 | 100 | 97.9 |
| 50 | 100 | 100 | 100 | 99.8 | 93.4 |
| 60 | 100 | 100 | 100 | 98.7 | 80.1 |
| 70 | 100 | 100 | 99.8 | 95.6 | 58.0 |