TABLE 5.
Percentage of simulated patients achieving fT>MIC targets in ELF
| fT>MIC target (%) and dosage regimen | % simulated patients achieving target at MIC (mg/liter) of: |
||||
|---|---|---|---|---|---|
| 0.125 | 0.25 | 0.5 | 1 | 2 | |
| 600 mg q12h, 1-h infusion | |||||
| 17 | 100 | 100 | 98.7 | 81.7 | 26.8 |
| 20 | 100 | 100 | 97.8 | 71.1 | 17.7 |
| 25 | 100 | 99.9 | 93.3 | 56.1 | 9.5 |
| 40 | 99.8 | 95.2 | 65.6 | 16.6 | 1.4 |
| 42 | 99.7 | 93.3 | 61.7 | 13.9 | 0.9 |
| 600 mg q8h, 1-h infusion | |||||
| 17 | 100 | 100 | 99.9 | 94.7 | 58.5 |
| 20 | 100 | 100 | 99.8 | 91.4 | 47.4 |
| 25 | 100 | 100 | 99.2 | 85.0 | 33.5 |
| 40 | 100 | 99.8 | 92.5 | 57.0 | 9.8 |
| 42 | 100 | 99.7 | 90.9 | 52.5 | 8.0 |