FIG 5.

Cytotoxicity toward specific mammalian cell lines is reduced in lead compounds. (a) Cytotoxicity, measured as a percentage of total LDH released from IB3-1 cells treated with 0.1% Triton X-100 (100% cytotoxicity), was significantly reduced in the presence of several lead compounds. The data (means and SEM) are representative of three independent biological experiments. (b) Selected lead compounds were tested against A549, DU145, and HeLa cell lines. The data represent four independent biological replicates, and all the data points are normalized to Triton X-100 as described for panel a. One-way ANOVA was performed, with Bonferroni corrective testing on all data sets, and comparison to an MeOH control is presented; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001.