FIG 6.

Influence of HHQ analogues on PQS-dependent virulence phenotypes in P. aeruginosa. Phenazine production (a) and pqsA-lacZ promoter activity (b) were quantified in a PAO1 pqsA mutant in the presence of HHQ, PQS, and lead compounds. The data are presented as means and SEM and are representative of at least three independent biological replicates. One-way ANOVA was performed, with Bonferroni corrective testing, and statistical significance relative to the MeOH control is presented; **, P ≤ 0.01; ***, P ≤ 0.001.